Showing posts with label Merck. Show all posts
Showing posts with label Merck. Show all posts

Tuesday, 12 March 2013

Niacin, Statins And Difficulties Of Drug Discovery


John LaMattina, Contributor
Former president of Pfizer Global Research covering news in pharma.


About a dozen years ago, a team of Merck scientists met with upper management to discuss a new approach for treating cardiovascular disease. The approach was simple, but clever. The scientists had a way of turning a well known and widely used drug, niacin, into an even better and safer drug, thereby expanding its usage.

Niacin, also known as vitamin B3, is known to raise HDL (“good cholesterol”) by about 25% as well as modestly lower LDL (“bad cholesterol”) and triglycerides. It had been used for decades to help patients control their blood lipid levels based on results from a trial done in the 1960s known as the Coronary Drug Project, which looked at niacin versus placebo in men who had a previous heart attack over a period of five years. While niacin showed no difference from placebo in the death rate of the men in this study, fewer patients on niacin had a non-fatal heart attack or stroke, by 26% and 24%, respectively. This study provides the basis for the use of niacin in cardiovascular disease.

Thursday, 22 March 2012

Baldness drug Propecia 'risking men's sexual health'

Simon MundieBy Simon Mundie
             Newsbeat reporterJames 
Young men could be risking their sexual health by taking a commonly used anti-baldness drug, claim some doctors.
They say finasteride, sold in the UK as Propecia, can cause serious side effects and isn't adequately labelled.
A quarter of men in their 20s show signs of male pattern baldness, with six and a half million males in the UK affected.
Propecia manufacturer Merck says it continually monitors the drug's safety and has updated the label.
James, 26, from Edinburgh suffered side effects after using the drug.
"I noticed hair loss, hair coming out in the shower and on the pillow, and I freaked out basically.
"I went onto the internet and researched it. I found out there was a drug called Propecia, and soon enough I started buying that and it worked a treat."
The prescription pill is extremely effective at stopping hair loss and in clinical trials nine out of 10 men didn't lose any more hair over a five year period.
Drugs' company Merck, which manufactures Propecia, claims on its website that less than 2% of men could suffer sexual side effects.
'Completely impotent'
It mentions things like difficulty achieving an erection, but says the problems will go away for men who stop taking the drug.
For James, that was when the problems started. He'd stopped taking the drug after noticing he had less interest in sex - but he says things soon got worse.
"After about three weeks all hell broke loose. I more or less became completely impotent."
He went to see a specialist a few months later.
After about three weeks all hell broke loose... It did work well for my hair, but the cost is ridiculous - losing my sex-life
James, 26
"He put me on testosterone therapy, which is a lifelong commitment", says James.
"Unfortunately that didn't work either. I went back to him six months later and he offered me the chance of a penile implant."
There are doctors in Ireland and the US who claim cases like James's aren't unusual and that the drug's labelling is inadequate.
Merck say they continually monitor its safety and have recently changed the labelling after reports of sexual side effects continuing after people had stopped taking the drug.
They also claim those cases are extremely rare and could be caused by something other than Propecia itself.
But James is convinced it was his decision to take the drug that caused his problem.
"Every day I wish could turn back the clock.
"It did work well for my hair, but the cost is ridiculous - losing my sex-life.
"It's happening to lots and lots of men- and it's about time people woke up to it."

http://www.bbc.co.uk/newsbeat/12040303